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Assay Detail

CHEMBL3380894

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiplasmodial activity against Trypanosoma brucei rhodesiense assessed as growth inhibition
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trypanosoma brucei rhodesiense
Confidence 1 — Organism
Curated By Autocuration

Target

Trypanosoma brucei rhodesiense (CHEMBL612348)
Type ORGANISM
Organism Trypanosoma brucei rhodesiense

Publication

Exploring in vitro and in vivo Hsp90 inhibitors activity against human protozoan parasites.
Giannini G, Battistuzzi G.
Bioorg Med Chem Lett (2015) 25 : 462 -465
PubMed 25547934 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 7.63 9.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3353321 1 9.00
CHEMBL3234764 1 9.00
CHEMBL3234770 1 8.52
CHEMBL166 MELARSOPROL 3.0 1 8.52
CHEMBL3353320 1 8.40
CHEMBL3353319 1 8.40
CHEMBL1941079 1 8.00
CHEMBL1941077 1 7.92
CHEMBL1941052 1 7.85
CHEMBL1941061 1 7.75
CHEMBL1941055 1 7.75
CHEMBL1941050 1 7.66
CHEMBL1940934 1 6.90
CHEMBL1940941 1 6.12
CHEMBL3233488 1 6.01
CHEMBL3233485 1 4.28

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3353321 IC50 = 1.0 nM 9.00
CHEMBL3234764 IC50 = 1.0 nM 9.00
CHEMBL3234770 IC50 = 3.0 nM 8.52
CHEMBL166 MELARSOPROL IC50 = 3.0 nM 8.52
CHEMBL3353320 IC50 = 4.0 nM 8.40
CHEMBL3353319 IC50 = 4.0 nM 8.40
CHEMBL1941079 IC50 = 10.0 nM 8.00
CHEMBL1941077 IC50 = 12.0 nM 7.92
CHEMBL1941052 IC50 = 14.0 nM 7.85
CHEMBL1941061 IC50 = 18.0 nM 7.75
CHEMBL1941055 IC50 = 18.0 nM 7.75
CHEMBL1941050 IC50 = 22.0 nM 7.66
CHEMBL1940934 IC50 = 126.0 nM 6.90
CHEMBL1940941 IC50 = 763.0 nM 6.12
CHEMBL3233488 IC50 = 971.0 nM 6.01
CHEMBL3233485 IC50 = 52400.0 nM 4.28