Assay Detail
Functional
CHEMBL3381045
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Induction of Her2 degradation in human BT474 cells assessed as inhibition of signal by immunocytochemistry
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | BT-474 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Fragment-based hit discovery and structure-based optimization of aminotriazoloquinazolines as novel Hsp90 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.79 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 8.00 |
| CHEMBL3310151 | — | — | 1 | 5.69 |
| CHEMBL3309997 | — | — | 1 | 5.59 |
| CHEMBL3309998 | — | — | 1 | 5.54 |
| CHEMBL3309990 | — | — | 1 | 5.17 |
| CHEMBL3309995 | — | — | 1 | 4.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL252164 | LUMINESPIB | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3310151 | — | IC50 | = | 2050.0 | nM | 5.69 |
| CHEMBL3309997 | — | IC50 | = | 2560.0 | nM | 5.59 |
| CHEMBL3309998 | — | IC50 | = | 2880.0 | nM | 5.54 |
| CHEMBL3309990 | — | IC50 | = | 6706.0 | nM | 5.17 |
| CHEMBL3309995 | — | IC50 | = | 18147.0 | nM | 4.74 |