Assay Detail
Binding
CHEMBL3381316
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]8-OH-DPAT from human recombinant 5-HT1A receptor expressed in HeLa cells after 30 mins by liquid scintillation counting
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-affinity/activity relationships of 1,4-dioxa-spiro[4.5]decane based ligands at α<alpha>1 and 5-HT1A receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 27 | 7.37 | 8.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2234448 | — | — | 1 | 8.29 |
| CHEMBL3342858 | — | — | 1 | 8.05 |
| CHEMBL3342852 | — | — | 1 | 8.03 |
| CHEMBL3342853 | — | — | 1 | 7.84 |
| CHEMBL3342857 | — | — | 1 | 7.80 |
| CHEMBL3342862 | — | — | 1 | 7.69 |
| CHEMBL3342870 | — | — | 1 | 7.61 |
| CHEMBL3342867 | — | — | 1 | 7.57 |
| CHEMBL3342874 | — | — | 1 | 7.48 |
| CHEMBL3342863 | — | — | 1 | 7.44 |
| CHEMBL3342868 | — | — | 1 | 7.43 |
| CHEMBL3342861 | — | — | 1 | 7.37 |
| CHEMBL3342871 | — | — | 1 | 7.36 |
| CHEMBL3341769 | — | — | 1 | 7.33 |
| CHEMBL3342860 | — | — | 1 | 7.30 |
| CHEMBL3342866 | — | — | 1 | 7.28 |
| CHEMBL3342859 | — | — | 1 | 7.23 |
| CHEMBL3342872 | — | — | 1 | 7.22 |
| CHEMBL3342864 | — | — | 1 | 7.19 |
| CHEMBL3342869 | — | — | 1 | 7.16 |
| CHEMBL3342875 | — | — | 1 | 7.10 |
| CHEMBL3342855 | — | — | 1 | 7.09 |
| CHEMBL3342876 | — | — | 1 | 7.06 |
| CHEMBL3342854 | — | — | 1 | 6.93 |
| CHEMBL3342873 | — | — | 1 | 6.84 |
| CHEMBL3342856 | — | — | 1 | 6.80 |
| CHEMBL3342865 | — | — | 1 | 6.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2234448 | — | Ki | = | 5.129 | nM | 8.29 |
| CHEMBL3342858 | — | Ki | = | 8.913 | nM | 8.05 |
| CHEMBL3342852 | — | Ki | = | 9.333 | nM | 8.03 |
| CHEMBL3342853 | — | Ki | = | 14.45 | nM | 7.84 |
| CHEMBL3342857 | — | Ki | = | 15.85 | nM | 7.80 |
| CHEMBL3342862 | — | Ki | = | 20.42 | nM | 7.69 |
| CHEMBL3342870 | — | Ki | = | 24.55 | nM | 7.61 |
| CHEMBL3342867 | — | Ki | = | 26.92 | nM | 7.57 |
| CHEMBL3342874 | — | Ki | = | 33.11 | nM | 7.48 |
| CHEMBL3342863 | — | Ki | = | 36.31 | nM | 7.44 |
| CHEMBL3342868 | — | Ki | = | 37.15 | nM | 7.43 |
| CHEMBL3342861 | — | Ki | = | 42.66 | nM | 7.37 |
| CHEMBL3342871 | — | Ki | = | 43.65 | nM | 7.36 |
| CHEMBL3341769 | — | Ki | = | 46.77 | nM | 7.33 |
| CHEMBL3342860 | — | Ki | = | 50.12 | nM | 7.30 |
| CHEMBL3342866 | — | Ki | = | 52.48 | nM | 7.28 |
| CHEMBL3342859 | — | Ki | = | 58.88 | nM | 7.23 |
| CHEMBL3342872 | — | Ki | = | 60.26 | nM | 7.22 |
| CHEMBL3342864 | — | Ki | = | 64.57 | nM | 7.19 |
| CHEMBL3342869 | — | Ki | = | 69.18 | nM | 7.16 |
| CHEMBL3342875 | — | Ki | = | 79.43 | nM | 7.10 |
| CHEMBL3342855 | — | Ki | = | 81.28 | nM | 7.09 |
| CHEMBL3342876 | — | Ki | = | 87.1 | nM | 7.06 |
| CHEMBL3342854 | — | Ki | = | 117.49 | nM | 6.93 |
| CHEMBL3342873 | — | Ki | = | 144.54 | nM | 6.84 |
| CHEMBL3342856 | — | Ki | = | 158.49 | nM | 6.80 |
| CHEMBL3342865 | — | Ki | = | 323.59 | nM | 6.49 |