Assay Detail
Binding
CHEMBL3382374
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Inhibition of human cathepsin L using Z-Phe-Arg-pNA chromogenic substrate fluorogenic substrate incubated for 30 mins
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
3-Cyano-3-aza-β-amino Acid Derivatives as Inhibitors of Human Cysteine Cathepsins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.17 | 6.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3342185 | — | — | 1 | 6.73 |
| CHEMBL3342184 | — | — | 1 | 6.64 |
| CHEMBL3342183 | — | — | 1 | 6.24 |
| CHEMBL3342186 | — | — | 1 | 5.77 |
| CHEMBL371064 | BALICATIB | 2.0 | 1 | 5.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3342185 | — | Ki | = | 185.0 | nM | 6.73 |
| CHEMBL3342184 | — | Ki | = | 228.0 | nM | 6.64 |
| CHEMBL3342183 | — | Ki | = | 573.0 | nM | 6.24 |
| CHEMBL3342186 | — | Ki | = | 1690.0 | nM | 5.77 |
| CHEMBL371064 | BALICATIB | Ki | = | 3260.0 | nM | 5.49 |