Assay Detail
Binding
CHEMBL3382385
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Inhibition of BCL-XL (unknown origin) expressed in mcl-1 deficient MEF assessed as induction of cell killing incubated for 48 hrs in presence of 10% FBS by Cell titerGlo reagent based assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 7.28 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3342195 | — | — | 1 | 8.00 |
| CHEMBL3342196 | — | — | 1 | 7.70 |
| CHEMBL3342192 | — | — | 1 | 7.22 |
| CHEMBL3342194 | — | — | 1 | 6.19 |
| CHEMBL3342189 | — | — | 1 | - |
| CHEMBL3342190 | — | — | 1 | - |
| CHEMBL3342191 | A-1107969 | — | 1 | - |
| CHEMBL3342193 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3342195 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3342196 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3342192 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3342194 | — | EC50 | = | 640.0 | nM | 6.19 |
| CHEMBL3342189 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL3342190 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL3342191 | A-1107969 | EC50 | > | 5000.0 | nM | - |
| CHEMBL3342193 | — | EC50 | > | 5000.0 | nM | - |