Assay Detail
Functional
CHEMBL3382386
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Cytotoxicity against BCL-XL-dependent human NCI-H146 cells in presence of 10% human serum incubated for 48 hrs by Cell titerGlo reagent based assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H146 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.87 | 7.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3342333 | — | — | 1 | 7.29 |
| CHEMBL3342332 | A-1155463 | — | 1 | 7.19 |
| CHEMBL3342334 | — | — | 1 | 6.90 |
| CHEMBL3342198 | — | — | 1 | 6.75 |
| CHEMBL3342197 | — | — | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3342333 | — | EC50 | = | 51.0 | nM | 7.29 |
| CHEMBL3342332 | A-1155463 | EC50 | = | 65.0 | nM | 7.19 |
| CHEMBL3342334 | — | EC50 | = | 126.0 | nM | 6.90 |
| CHEMBL3342198 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL3342197 | — | EC50 | = | 600.0 | nM | 6.22 |