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Assay Detail

CHEMBL3382691

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Inhibition of CYP2C19 (unknown origin)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Cytochrome P450 2C19 (CHEMBL3622)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Anilinotriazoles as potent gamma secretase modulators.
Velter AI, Bischoff FP, Berthelot D, De Cleyn M, Oehlrich D, Jaroskova L, Macdonald G, Minne G, Pieters S, Rombouts F, Van Brandt S, Van Roosbroeck Y, Surkyn M, Trabanco AA, Tresadern G, Wu T, Borghys H, Mercken M, Masungi C, Gijsen H.
Bioorg Med Chem Lett (2014) 24 : 5805 -5813
PubMed 25454273 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 2 5.06 5.46

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2151164 1 5.46
CHEMBL3353099 1 4.66

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2151164 IC50 = 3500.0 nM 5.46
CHEMBL3353099 IC50 = 22100.0 nM 4.66