Assay Detail

CHEMBL3383006

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ADMET

Cytotoxicity against human NHSF46 cells after 48 hrs by XTT/PMS assay

ChEMBL ↗

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Target

ADMET (CHEMBL612558) ↗

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Primary target ADMET

CHEMBL612558

Anchored from Assay target.

Protein identity ADMET

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	ADMET
Organism	Homo sapiens
Cell Type	NHSF46
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

ADMET (CHEMBL612558) ↗

Type

ADMET

Publication

Development of a new benzophenone-diketopiperazine-type potent antimicrotubule agent possessing a 2-pyridine structure.

Hayashi Y, Takeno H, Chinen T, Muguruma K, Okuyama K, Taguchi A, Takayama K, Yakushiji F, Miura M, Usui T, Hayashi Y.
ACS Med Chem Lett (2014) 5 : 1094 -1098
PubMed 25313318 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	7.11	7.11

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL3342339	—	—	1	7.11

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL3342339	—	IC50	=	77.0	nM	7.11