Assay Detail
Functional
CHEMBL3383097
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In-vivo occupancy at PDE2 in sc dosed Wistar rat brain using [3H]labeled compound in presence of 2.5 mg/kg, sc PDE10 inhibitor MP10
2
Total Activities
1
Compounds Tested
2
Activity Types
2
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-Based Design of a Potent, Selective, and Brain Penetrating PDE2 Inhibitor with Demonstrated Target Engagement.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| ED50 | 1 | - | - |
| EC50 | 1 | 7.68 | 7.68 |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| DOSE | DOSE | 2.5 | mg.kg-1 | — |
| ROUTE | ROUTE | - | — | Subcutaneous |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3331521 | — | — | 2 | 7.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3331521 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL3331521 | — | ED50 | = | 4.3 | mg.kg-1 | - |