Assay Detail
Binding
CHEMBL3383445
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Inhibition of Bcl-xL/Bak (unknown origin) interaction
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Pro-apoptotic meiogynin A derivatives that target Bcl-xL and Mcl-1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 4.93 | 5.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3339154 | — | — | 1 | 5.64 |
| CHEMBL3339156 | — | — | 1 | 5.34 |
| CHEMBL3339155 | — | — | 1 | 5.12 |
| CHEMBL556082 | MEIOGYNIN A | — | 1 | 5.05 |
| CHEMBL3339153 | — | — | 1 | 4.40 |
| CHEMBL3339152 | — | — | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3339154 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL3339156 | — | Ki | = | 4600.0 | nM | 5.34 |
| CHEMBL3339155 | — | Ki | = | 7500.0 | nM | 5.12 |
| CHEMBL556082 | MEIOGYNIN A | Ki | = | 9000.0 | nM | 5.05 |
| CHEMBL3339153 | — | Ki | = | 40000.0 | nM | 4.40 |
| CHEMBL3339152 | — | Ki | = | 100000.0 | nM | 4.00 |