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Compound Detail

CHEMBL3339155

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CC(C)=CCC[C@H](C)[C@@H]1C=C[C@]2(C(=O)O)[C@@H](CC(C)=C[C@H]2/C=C(\C)c2ccc(C(=O)O)cc2)C1

Basic Information

ChEMBL ID CHEMBL3339155
Phase Preclinical
Structure Type MOL
InChI Key YEQLBOWLDTXBBB-VKEJBPGJSA-N
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

462.6
MW (Da)
7.40
ALogP
2
HBA
2
HBD
74.6
PSA (Ų)
0.39
QED
1
Ro5 Violations
8
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C30H38O4
MW 462.63
Aromatic Rings 1
Heavy Atoms 34
NP-Likeness 2.05

Activity Summary

Ki 4 meas. best 5.12

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Bcl-xL/BAK
CHEMBL3137283
Ki 5.12 5.12 7500.0 2
Induced myeloid leukemia cell differentiation protein Mcl-1/BH3-interacting domain death agonist
CHEMBL3430886
Ki 4.8 4.8 15900.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
25266781 10.1016/j.bmcl.2014.09.004 NON-PROTEIN TARGET 3
25266781 10.1016/j.bmcl.2014.09.004 Bcl-xL/BAK 1
25266781 10.1016/j.bmcl.2014.09.004 Induced myeloid leukemia cell differentiation protein Mcl-1/BH3-interacting domain death agonist 1
33333396 10.1016/j.ejmech.2020.113038 Induced myeloid leukemia cell differentiation protein Mcl-1/BH3-interacting domain death agonist 1
33333396 10.1016/j.ejmech.2020.113038 Bcl-xL/BAK 1

Data from ChEMBL 36 via Core Engine