Assay Detail
Binding
CHEMBL3383446
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Mcl1/Bid (unknown origin) interaction
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Induced myeloid leukemia cell differentiation protein Mcl-1/BH3-interacting domain death agonist (CHEMBL3430886) ↗| Type | PROTEIN-PROTEIN INTERACTION |
| Organism | Homo sapiens |
Publication
Pro-apoptotic meiogynin A derivatives that target Bcl-xL and Mcl-1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.06 | 5.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL556082 | MEIOGYNIN A | — | 1 | 5.42 |
| CHEMBL3339154 | — | — | 1 | 5.38 |
| CHEMBL3339156 | — | — | 1 | 5.04 |
| CHEMBL3339153 | — | — | 1 | 4.89 |
| CHEMBL3339152 | — | — | 1 | 4.84 |
| CHEMBL3339155 | — | — | 1 | 4.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL556082 | MEIOGYNIN A | Ki | = | 3800.0 | nM | 5.42 |
| CHEMBL3339154 | — | Ki | = | 4200.0 | nM | 5.38 |
| CHEMBL3339156 | — | Ki | = | 9100.0 | nM | 5.04 |
| CHEMBL3339153 | — | Ki | = | 12900.0 | nM | 4.89 |
| CHEMBL3339152 | — | Ki | = | 14400.0 | nM | 4.84 |
| CHEMBL3339155 | — | Ki | = | 15900.0 | nM | 4.80 |