Assay Detail
Binding
CHEMBL5113822
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Binding affinity to Mcl-1/Bid (unknown origin) assessed as inhibition constant by fluorescence polarization assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Induced myeloid leukemia cell differentiation protein Mcl-1/BH3-interacting domain death agonist (CHEMBL3430886) ↗| Type | PROTEIN-PROTEIN INTERACTION |
| Organism | Homo sapiens |
Publication
Development of Mcl-1 inhibitors for cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 6.09 | 7.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4848284 | — | — | 1 | 7.24 |
| CHEMBL5198484 | — | — | 1 | 6.97 |
| CHEMBL5204188 | — | — | 1 | 6.54 |
| CHEMBL5183108 | — | — | 1 | 6.50 |
| CHEMBL5181865 | — | — | 1 | 6.44 |
| CHEMBL5206049 | — | — | 1 | 6.38 |
| CHEMBL3265291 | — | — | 1 | 6.31 |
| CHEMBL5199461 | — | — | 1 | 6.13 |
| CHEMBL2030270 | — | — | 1 | 5.81 |
| CHEMBL5203252 | — | — | 1 | 5.66 |
| CHEMBL5207317 | — | — | 1 | 5.38 |
| CHEMBL3339156 | — | — | 1 | 5.04 |
| CHEMBL3339155 | — | — | 1 | 4.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4848284 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL5198484 | — | Ki | = | 106.0 | nM | 6.97 |
| CHEMBL5204188 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL5183108 | — | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL5181865 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL5206049 | — | Ki | = | 420.0 | nM | 6.38 |
| CHEMBL3265291 | — | Ki | = | 490.0 | nM | 6.31 |
| CHEMBL5199461 | — | Ki | = | 740.0 | nM | 6.13 |
| CHEMBL2030270 | — | Ki | = | 1550.0 | nM | 5.81 |
| CHEMBL5203252 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL5207317 | — | Ki | = | 4200.0 | nM | 5.38 |
| CHEMBL3339156 | — | Ki | = | 9100.0 | nM | 5.04 |
| CHEMBL3339155 | — | Ki | = | 15900.0 | nM | 4.80 |