Assay Detail
Binding
CHEMBL5113869
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Binding affinity to Bcl-xL/Bak (unknown origin) assessed as inhibition constant by fluorescence polarization assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Development of Mcl-1 inhibitors for cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 5.27 | 5.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5207317 | — | — | 1 | 5.64 |
| CHEMBL605114 | — | — | 1 | 5.43 |
| CHEMBL3339156 | — | — | 1 | 5.34 |
| CHEMBL3339155 | — | — | 1 | 5.12 |
| CHEMBL4161959 | — | — | 1 | 5.08 |
| CHEMBL335265 | — | — | 1 | 5.00 |
| CHEMBL596599 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5207317 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL605114 | — | Ki | = | 3700.0 | nM | 5.43 |
| CHEMBL3339156 | — | Ki | = | 4600.0 | nM | 5.34 |
| CHEMBL3339155 | — | Ki | = | 7500.0 | nM | 5.12 |
| CHEMBL4161959 | — | Ki | = | 8300.0 | nM | 5.08 |
| CHEMBL335265 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL596599 | — | Ki | > | 100000.0 | nM | - |