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Assay Detail

CHEMBL3383474

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiparasitic activity against bloodstream forms of Trypanosoma brucei rhodesiense STIB 900 assessed as inhibition of growth after 72 hrs by resazurin assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trypanosoma brucei rhodesiense
Confidence 1 — Organism
Curated By Autocuration

Target

Trypanosoma brucei rhodesiense (CHEMBL612348)
Type ORGANISM
Organism Trypanosoma brucei rhodesiense

Publication

Novel nitro(triazole/imidazole)-based heteroarylamides/sulfonamides as potential antitrypanosomal agents.
Papadopoulou MV, Bloomer WD, Rosenzweig HS, Wilkinson SR, Kaiser M.
Eur J Med Chem (2014) 87 : 79 -88
PubMed 25240098 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 22 5.59 6.73

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3358486 1 6.73
CHEMBL3358475 1 6.66
CHEMBL3358474 1 6.30
CHEMBL3358472 1 6.28
CHEMBL3358480 1 6.09
CHEMBL3358479 1 6.04
CHEMBL3358478 1 6.01
CHEMBL3358487 1 6.01
CHEMBL3358473 1 5.80
CHEMBL3358488 1 5.76
CHEMBL2070694 1 5.70
CHEMBL3358485 1 5.65
CHEMBL2070540 1 5.45
CHEMBL3358483 1 5.33
CHEMBL3358484 1 4.79
CHEMBL3358477 1 4.49
CHEMBL3358491 1 4.41
CHEMBL3358476 1 4.39
CHEMBL3358489 1 4.33
CHEMBL3358482 1 -
CHEMBL3358481 1 -
CHEMBL3358490 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3358486 IC50 = 187.0 nM 6.73
CHEMBL3358475 IC50 = 218.0 nM 6.66
CHEMBL3358474 IC50 = 505.0 nM 6.30
CHEMBL3358472 IC50 = 520.0 nM 6.28
CHEMBL3358480 IC50 = 810.0 nM 6.09
CHEMBL3358479 IC50 = 915.0 nM 6.04
CHEMBL3358478 IC50 = 980.0 nM 6.01
CHEMBL3358487 IC50 = 978.0 nM 6.01
CHEMBL3358473 IC50 = 1590.0 nM 5.80
CHEMBL3358488 IC50 = 1730.0 nM 5.76
CHEMBL2070694 IC50 = 1990.0 nM 5.70
CHEMBL3358485 IC50 = 2250.0 nM 5.65
CHEMBL2070540 IC50 = 3550.0 nM 5.45
CHEMBL3358483 IC50 = 4710.0 nM 5.33
CHEMBL3358484 IC50 = 16400.0 nM 4.79
CHEMBL3358477 IC50 = 32700.0 nM 4.49
CHEMBL3358491 IC50 = 39400.0 nM 4.41
CHEMBL3358476 IC50 = 40300.0 nM 4.39
CHEMBL3358489 IC50 = 47200.0 nM 4.33
CHEMBL3358482 IC50 - -
CHEMBL3358481 IC50 - -
CHEMBL3358490 IC50 = 172800.0 nM -