Assay Detail
Functional
CHEMBL3383480
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Trypanocidal activity against wild type bloodstream forms of Trypanosoma brucei brucei Lister 427 clone 221a assessed as inhibition of proliferation after 3 days by resazurin assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei brucei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel nitro(triazole/imidazole)-based heteroarylamides/sulfonamides as potential antitrypanosomal agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.67 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL166 | MELARSOPROL | 3.0 | 1 | 8.22 |
| CHEMBL3358487 | — | — | 1 | 6.36 |
| CHEMBL3358475 | — | — | 1 | 6.21 |
| CHEMBL3358488 | — | — | 1 | 5.87 |
| CHEMBL2070694 | — | — | 1 | 5.64 |
| CHEMBL3358473 | — | — | 1 | 5.53 |
| CHEMBL3358480 | — | — | 1 | 5.52 |
| CHEMBL3358478 | — | — | 1 | 5.01 |
| CHEMBL3358474 | — | — | 1 | 4.81 |
| CHEMBL3358472 | — | — | 1 | 4.64 |
| CHEMBL3358479 | — | — | 1 | 4.57 |
| CHEMBL3358485 | — | — | 1 | - |
| CHEMBL3358486 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL166 | MELARSOPROL | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3358487 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL3358475 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL3358488 | — | IC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL2070694 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL3358473 | — | IC50 | = | 2940.0 | nM | 5.53 |
| CHEMBL3358480 | — | IC50 | = | 3020.0 | nM | 5.52 |
| CHEMBL3358478 | — | IC50 | = | 9690.0 | nM | 5.01 |
| CHEMBL3358474 | — | IC50 | = | 15460.0 | nM | 4.81 |
| CHEMBL3358472 | — | IC50 | = | 22950.0 | nM | 4.64 |
| CHEMBL3358479 | — | IC50 | = | 26830.0 | nM | 4.57 |
| CHEMBL3358485 | — | IC50 | > | 7990.0 | nM | - |
| CHEMBL3358486 | — | IC50 | > | 930.0 | nM | - |