Assay Detail
Binding
CHEMBL3383777
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Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated for 20 mins by Ellman method
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and antiprotozoal activity of oligomethylene- and p-phenylene-bis(methylene)-linked bis(+)-huprines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.44 | 9.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL140476 | HUPRINE Y | — | 1 | 9.21 |
| CHEMBL3353041 | — | — | 1 | 7.76 |
| CHEMBL3353040 | — | — | 1 | 7.14 |
| CHEMBL3353039 | — | — | 1 | 6.72 |
| CHEMBL3353042 | — | — | 1 | 6.37 |
| CHEMBL3353043 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL140476 | HUPRINE Y | IC50 | = | 0.61 | nM | 9.21 |
| CHEMBL3353041 | — | IC50 | = | 17.5 | nM | 7.76 |
| CHEMBL3353040 | — | IC50 | = | 72.5 | nM | 7.14 |
| CHEMBL3353039 | — | IC50 | = | 192.0 | nM | 6.72 |
| CHEMBL3353042 | — | IC50 | = | 431.0 | nM | 6.37 |
| CHEMBL3353043 | — | IC50 | - | — | - |