Assay Detail
Binding
CHEMBL3383871
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant PDE4B2 assessed after 60 mins by IMAP fluorescence polarization assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
3',5'-cyclic-AMP phosphodiesterase 4B (CHEMBL275) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Modulation of cAMP-specific PDE without emetogenic activity: new sulfide-like PDE7 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.83 | 7.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | 7.01 |
| CHEMBL484928 | — | — | 1 | 5.75 |
| CHEMBL3359635 | — | — | 1 | 5.36 |
| CHEMBL3359633 | — | — | 1 | 5.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL63 | ROLIPRAM | IC50 | = | 97.9 | nM | 7.01 |
| CHEMBL484928 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL3359635 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL3359633 | — | IC50 | = | 6600.0 | nM | 5.18 |