Assay Detail
Functional
CHEMBL3384153
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Inhibition of LPS-induced NO production in C57BL/6 mouse macrophages preincubated with compound for 1 hr before LPS challenge measured after 24 hrs by Griess method
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | Macrophage |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel nitric oxide-releasing derivatives of brusatol as anti-inflammatory agents: design, synthesis, biological evaluation, and nitric oxide release studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.36 | 7.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3342212 | — | — | 1 | 7.33 |
| CHEMBL450464 | BRUSATOL | — | 1 | 7.30 |
| CHEMBL3342220 | — | — | 1 | 7.17 |
| CHEMBL3342210 | — | — | 1 | 7.05 |
| CHEMBL3342214 | — | — | 1 | 6.68 |
| CHEMBL3342215 | — | — | 1 | 6.42 |
| CHEMBL3342211 | — | — | 1 | 6.16 |
| CHEMBL3342217 | — | — | 1 | 5.96 |
| CHEMBL3342221 | — | — | 1 | 5.89 |
| CHEMBL3342213 | — | — | 1 | 5.68 |
| CHEMBL3342218 | — | — | 1 | 5.66 |
| CHEMBL3342219 | — | — | 1 | 4.96 |
| CHEMBL3342216 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3342212 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL450464 | BRUSATOL | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3342220 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL3342210 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL3342214 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL3342215 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL3342211 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL3342217 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3342221 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL3342213 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL3342218 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL3342219 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL3342216 | — | IC50 | > | 10000.0 | nM | - |