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Target Snapshot

CHEMBL612578 Target Snapshot

Macrophage · CELL-LINE

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353Compounds
179Assays
1Approved Drugs
189.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Macrophage as ChEMBL target CHEMBL612578. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Macrophage
CELL-LINE
As of 2026-09-14
ChEMBL target ID
CHEMBL612578
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Macrophage still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameMacrophage
Target TypeCELL-LINE
OrganismNone
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelMacrophage
UniProt AccessionN/A

Macrophage

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Macrophage.

Review nameMacrophage
Clinical Profile

Clinical Phase Distribution

1
Approved
1
Phase III
Assay Mix

Activity Type Distribution

IC50182.0
EC507.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL442972 8.89 IC50 1.3 Preclinical
CHEMBL429422 8.77 IC50 1.7 Preclinical
CHEMBL270002 8.72 IC50 1.9 Preclinical
CHEMBL252436 8.7 IC50 2.0 Preclinical
CHEMBL399763 8.7 IC50 2.0 Preclinical
CHEMBL192889 8.59 IC50 2.6 Preclinical
CHEMBL255794 8.52 IC50 3.0 Preclinical
CHEMBL402219 8.46 IC50 3.5 Preclinical
CHEMBL272108 8.43 IC50 3.7 Preclinical
CHEMBL2057918 8.4 IC50 4.0 Preclinical
Distribution

pChEMBL Value Distribution

11
5.0
14
5.5
15
6.0
11
6.5
18
7.0
16
7.5
12
8.0
7
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

DEXAMETHASONE
CHEMBL384467
Approved 1958
Properties Compare Identifier
Assay Landscape

Assay Landscape

179
Total Assays
132
Tested Compounds
4
Assay Types
Functional — 175 assays, 132 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 171 132 6.4
organism-based format 4 0 —
ADME — 2 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 2 0 —
Toxicity — 1 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 0 —
Unassigned — 1 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine