Compound Detail
CHEMBL399763
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Basic Information
| ChEMBL ID | CHEMBL399763 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NZRFILSWDBFAQV-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
392.5
MW (Da)
2.88
ALogP
5
HBA
2
HBD
78.4
PSA (Ų)
0.84
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 8.77
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Macrophage colony-stimulating factor 1 receptor CHEMBL1844 | IC50 | 8.77 | 8.735 | 1.7 | 2 |
| Macrophage CHEMBL612578 | IC50 | 8.7 | 8.7 | 2.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Macrophage colony-stimulating factor 1 receptor | IC50 | = | 1.7 | nM | 8.77 | Inhibition of human cytoplasmic FMS expressed in Sf9-baculovirus system after 80... | 18242992 |
| Macrophage | IC50 | = | 2.0 | nM | 8.7 | Inhibition of FMS-induced proliferation of bone marrow derived human macrophages | 18242992 |
| Macrophage colony-stimulating factor 1 receptor | IC50 | = | 2.0 | nM | 8.7 | Inhibition of FMS mediated phosphorylation using SYEGNSYTFIDPTQ as substrate aft... | 22039836 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18242992 | 10.1016/j.bmcl.2008.01.059 | Macrophage colony-stimulating factor 1 receptor | 1 |
| 18242992 | 10.1016/j.bmcl.2008.01.059 | Macrophage | 1 |
| 22039836 | 10.1021/jm200900q | Macrophage colony-stimulating factor 1 receptor | 1 |
Data from ChEMBL 36 via Core Engine