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Assay Detail

CHEMBL3384154

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against C57BL/6 mouse macrophages after 24 hrs by MTT assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Mus musculus
Cell Type Macrophage
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

ADMET (CHEMBL612558)
Type ADMET

Publication

Novel nitric oxide-releasing derivatives of brusatol as anti-inflammatory agents: design, synthesis, biological evaluation, and nitric oxide release studies.
Tang W, Xie J, Xu S, Lv H, Lin M, Yuan S, Bai J, Hou Q, Yu S.
J Med Chem (2014) 57 : 7600 -7612
PubMed 25179783 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 6.08 6.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL450464 BRUSATOL 1 6.85
CHEMBL3342212 1 6.82
CHEMBL3342210 1 6.10
CHEMBL3342215 1 6.09
CHEMBL3342214 1 5.92
CHEMBL3342211 1 5.89
CHEMBL3342217 1 5.52
CHEMBL3342218 1 5.41
CHEMBL3342213 1 -
CHEMBL3342216 1 -
CHEMBL3342219 1 -
CHEMBL3342220 1 -
CHEMBL3342221 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL450464 BRUSATOL IC50 = 140.0 nM 6.85
CHEMBL3342212 IC50 = 150.0 nM 6.82
CHEMBL3342210 IC50 = 790.0 nM 6.10
CHEMBL3342215 IC50 = 820.0 nM 6.09
CHEMBL3342214 IC50 = 1200.0 nM 5.92
CHEMBL3342211 IC50 = 1300.0 nM 5.89
CHEMBL3342217 IC50 = 3000.0 nM 5.52
CHEMBL3342218 IC50 = 3900.0 nM 5.41
CHEMBL3342213 IC50 > 10000.0 nM -
CHEMBL3342216 IC50 > 10000.0 nM -
CHEMBL3342219 IC50 > 10000.0 nM -
CHEMBL3342220 IC50 > 10000.0 nM -
CHEMBL3342221 IC50 > 10000.0 nM -