Assay Detail
Binding
CHEMBL3384491
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Inhibition of human recombinant MAGL expressed in HEK293 cells using 2-AG as substrate assessed as remaining activity at 10 uM
16
Total Activities
15
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Piperazine and piperidine carboxamides and carbamates as inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 15 | - | - |
| IC50 | 1 | 9.15 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3356958 | — | — | 2 | 9.15 |
| CHEMBL3356963 | — | — | 1 | - |
| CHEMBL3356964 | — | — | 1 | - |
| CHEMBL3356965 | — | — | 1 | - |
| CHEMBL3356966 | — | — | 1 | - |
| CHEMBL3356967 | — | — | 1 | - |
| CHEMBL3356968 | — | — | 1 | - |
| CHEMBL3356969 | — | — | 1 | - |
| CHEMBL3356970 | — | — | 1 | - |
| CHEMBL2164594 | — | — | 1 | - |
| CHEMBL3356972 | — | — | 1 | - |
| CHEMBL3356973 | — | — | 1 | - |
| CHEMBL3356982 | — | — | 1 | - |
| CHEMBL3356983 | — | — | 1 | - |
| CHEMBL3356984 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3356958 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL3356958 | — | Activity | = | 51.0 | % | - |
| CHEMBL3356963 | — | Activity | = | 62.0 | % | - |
| CHEMBL3356964 | — | Activity | = | 96.0 | % | - |
| CHEMBL3356965 | — | Activity | = | 58.0 | % | - |
| CHEMBL3356966 | — | Activity | = | 92.0 | % | - |
| CHEMBL3356967 | — | Activity | = | 86.0 | % | - |
| CHEMBL3356968 | — | Activity | = | 93.0 | % | - |
| CHEMBL3356969 | — | Activity | = | 101.0 | % | - |
| CHEMBL3356970 | — | Activity | = | 94.0 | % | - |
| CHEMBL2164594 | — | Activity | = | 98.0 | % | - |
| CHEMBL3356972 | — | Activity | = | 102.0 | % | - |
| CHEMBL3356973 | — | Activity | = | 78.0 | % | - |
| CHEMBL3356982 | — | Activity | = | 85.0 | % | - |
| CHEMBL3356983 | — | Activity | = | 92.0 | % | - |
| CHEMBL3356984 | — | Activity | = | 89.0 | % | - |