Assay Detail
Binding
CHEMBL3384574
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Inhibition of COX-1 in human OVCAR3 cells by cell-based assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | OVCAR-3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design of Fluorine-Containing 3,4-Diarylfuran-2(5H)-ones as Selective COX-1 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.21 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3357103 | — | — | 1 | 6.75 |
| CHEMBL3357104 | — | — | 1 | 6.44 |
| CHEMBL3357099 | — | — | 1 | 6.11 |
| CHEMBL3357095 | — | — | 1 | 5.55 |
| CHEMBL3357106 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3357103 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL3357104 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL3357099 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL3357095 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL3357106 | — | IC50 | > | 4000.0 | nM | - |