Assay Detail
Binding
CHEMBL3384852
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Inhibition of human NPP1 using p-Nph-5'-TMP as substrate
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (CHEMBL5925) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Imidazopyridine- and purine-thioacetamide derivatives: potent inhibitors of nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 6.63 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3360892 | — | — | 1 | 8.30 |
| CHEMBL3360893 | — | — | 1 | 7.70 |
| CHEMBL3360884 | — | — | 1 | 7.53 |
| CHEMBL3360901 | — | — | 1 | 7.45 |
| CHEMBL3360878 | — | — | 1 | 7.36 |
| CHEMBL3360885 | — | — | 1 | 6.90 |
| CHEMBL3360880 | — | — | 1 | 6.88 |
| CHEMBL3360882 | — | — | 1 | 6.86 |
| CHEMBL3360899 | — | — | 1 | 6.82 |
| CHEMBL3360883 | — | — | 1 | 6.72 |
| CHEMBL1433061 | — | — | 1 | 6.66 |
| CHEMBL3360879 | — | — | 1 | 6.55 |
| CHEMBL3360895 | — | — | 1 | 6.00 |
| CHEMBL3360897 | — | — | 1 | 5.46 |
| CHEMBL3360898 | — | — | 1 | 5.44 |
| CHEMBL3360894 | — | — | 1 | 5.09 |
| CHEMBL3360896 | — | — | 1 | 4.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3360892 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL3360893 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL3360884 | — | Ki | = | 29.6 | nM | 7.53 |
| CHEMBL3360901 | — | Ki | = | 35.8 | nM | 7.45 |
| CHEMBL3360878 | — | Ki | = | 44.2 | nM | 7.36 |
| CHEMBL3360885 | — | Ki | = | 127.0 | nM | 6.90 |
| CHEMBL3360880 | — | Ki | = | 131.0 | nM | 6.88 |
| CHEMBL3360882 | — | Ki | = | 137.0 | nM | 6.86 |
| CHEMBL3360899 | — | Ki | = | 152.0 | nM | 6.82 |
| CHEMBL3360883 | — | Ki | = | 192.0 | nM | 6.72 |
| CHEMBL1433061 | — | Ki | = | 217.0 | nM | 6.66 |
| CHEMBL3360879 | — | Ki | = | 281.0 | nM | 6.55 |
| CHEMBL3360895 | — | Ki | = | 1010.0 | nM | 6.00 |
| CHEMBL3360897 | — | Ki | = | 3480.0 | nM | 5.46 |
| CHEMBL3360898 | — | Ki | = | 3650.0 | nM | 5.44 |
| CHEMBL3360894 | — | Ki | = | 8040.0 | nM | 5.09 |
| CHEMBL3360896 | — | Ki | = | 11000.0 | nM | 4.96 |