Assay Detail
Binding
CHEMBL3384855
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Competitive inhibition of human NPP1 using ATP as substrate by Lineweaver-Burk plot analysis
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (CHEMBL5925) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Imidazopyridine- and purine-thioacetamide derivatives: potent inhibitors of nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 4.64 | 5.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3360884 | — | — | 1 | 5.27 |
| CHEMBL3360885 | — | — | 1 | 5.12 |
| CHEMBL3360882 | — | — | 1 | 5.01 |
| CHEMBL3360883 | — | — | 1 | 4.97 |
| CHEMBL3360893 | — | — | 1 | 4.84 |
| CHEMBL3360879 | — | — | 1 | 4.80 |
| CHEMBL3360892 | — | — | 1 | 4.75 |
| CHEMBL1433061 | — | — | 1 | 4.65 |
| CHEMBL3360901 | — | — | 1 | 4.65 |
| CHEMBL3360899 | — | — | 1 | 4.57 |
| CHEMBL3360878 | — | — | 1 | 4.54 |
| CHEMBL3360880 | — | — | 1 | 4.52 |
| CHEMBL3360895 | — | — | 1 | 4.47 |
| CHEMBL3360894 | — | — | 1 | 4.38 |
| CHEMBL3360898 | — | — | 1 | 4.17 |
| CHEMBL3360897 | — | — | 1 | 4.11 |
| CHEMBL3360896 | — | — | 1 | 4.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3360884 | — | Ki | = | 5340.0 | nM | 5.27 |
| CHEMBL3360885 | — | Ki | = | 7590.0 | nM | 5.12 |
| CHEMBL3360882 | — | Ki | = | 9780.0 | nM | 5.01 |
| CHEMBL3360883 | — | Ki | = | 10800.0 | nM | 4.97 |
| CHEMBL3360893 | — | Ki | = | 14300.0 | nM | 4.84 |
| CHEMBL3360879 | — | Ki | = | 15700.0 | nM | 4.80 |
| CHEMBL3360892 | — | Ki | = | 18000.0 | nM | 4.75 |
| CHEMBL1433061 | — | Ki | = | 22300.0 | nM | 4.65 |
| CHEMBL3360901 | — | Ki | = | 22500.0 | nM | 4.65 |
| CHEMBL3360899 | — | Ki | = | 26700.0 | nM | 4.57 |
| CHEMBL3360878 | — | Ki | = | 29200.0 | nM | 4.54 |
| CHEMBL3360880 | — | Ki | = | 30200.0 | nM | 4.52 |
| CHEMBL3360895 | — | Ki | = | 33600.0 | nM | 4.47 |
| CHEMBL3360894 | — | Ki | = | 42200.0 | nM | 4.38 |
| CHEMBL3360898 | — | Ki | = | 67900.0 | nM | 4.17 |
| CHEMBL3360897 | — | Ki | = | 78000.0 | nM | 4.11 |
| CHEMBL3360896 | — | Ki | = | 89700.0 | nM | 4.05 |