Assay Detail
Binding
CHEMBL3385108
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]epibatidine from rat forebrain alpha2beta2 nAChR by competition binding assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor; alpha2/beta2 (CHEMBL1907592) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
Enantiopure Cyclopropane-Bearing Pyridyldiazabicyclo[3.3.0]octanes as Selective α4β2-nAChR Ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 9.03 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3356152 | — | — | 1 | 9.70 |
| CHEMBL1186374 | — | — | 1 | 9.52 |
| CHEMBL3356148 | — | — | 1 | 9.52 |
| CHEMBL3356151 | — | — | 1 | 9.40 |
| CHEMBL3356150 | — | — | 1 | 9.22 |
| CHEMBL3 | NICOTINE | 4.0 | 1 | 8.26 |
| CHEMBL3356149 | — | — | 1 | 7.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3356152 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL1186374 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL3356148 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL3356151 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL3356150 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL3 | NICOTINE | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL3356149 | — | Ki | = | 25.0 | nM | 7.60 |