Assay Detail
Functional
CHEMBL3385498
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Induction of GLP1 secretion in mouse STC1 cells incubated for 2 hrs by fluorescent bead based ELISA method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | STC1 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of 2-Pyridylpyrimidines as the First Orally Bioavailable GPR39 Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.29 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3342358 | — | — | 1 | 7.22 |
| CHEMBL3342379 | — | — | 1 | 6.70 |
| CHEMBL3342376 | — | — | 1 | 5.89 |
| CHEMBL3342377 | — | — | 1 | 5.36 |
| CHEMBL1200679 | ZINC CHLORIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3342358 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3342379 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3342376 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL3342377 | — | EC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL1200679 | ZINC CHLORIDE | EC50 | - | — | - |