Compound Detail

CHEMBL1200679

ZINC CHLORIDE

💊 Approved Drug

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💊 Approved Drug

[Cl-].[Cl-].[Zn+2]

ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID	CHEMBL1200679
Name	ZINC CHLORIDE
Phase	Approved
Structure Type	MOL
InChI Key	JIAARYAFYJHUJI-UHFFFAOYSA-L

NSC-529648 Zinc chloride Zincum muriaticum

Targets

Activities

Assay Types

PK Parameters

Publications

Known Names

136.3

MW (Da)

Parenteral

Molecular Formula	Cl2Zn
MW	136.30

B05XA12

zinc chloride

Level 1: BLOOD AND BLOOD FORMING ORGANS

Level 2: BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS

IC50 6 meas. best 5.96

EC50 2 meas. best 8.44

Ki 2 meas. best 5.36

Kd 1 meas. best 4.8

Target	Type	Best pChEMBL	Mean pChEMBL	Best (nM)	# Data
G-protein coupled receptor 39 CHEMBL3091266	EC50	8.44	8.44	3.6	1
Protein phosphatase 3 catalytic subunit alpha CHEMBL4445	IC50	5.96	5.96	1100.3	1
Carbonic anhydrase 2 CHEMBL205	IC50	5.94	5.94	1159.0	1
Tyrosine-protein kinase Fyn CHEMBL1841	IC50	5.73	5.73	1877.9	1
Epidermal growth factor receptor CHEMBL203	IC50	5.66	5.66	2188.4	1
Protein Gpr39 CHEMBL3091267	EC50	5.39	5.39	4038.0	1
Androgen receptor CHEMBL3072	Ki	5.36	5.36	4339.1	1
Androgen receptor CHEMBL3072	IC50	5.19	5.19	6508.6	1
Sodium-dependent noradrenaline transporter CHEMBL222	Ki	5.16	5.16	6950.4	1
Sodium-dependent noradrenaline transporter CHEMBL222	IC50	5.15	5.15	7008.3	1
Ubiquitin-conjugating enzyme E2 T CHEMBL4105763	Kd	4.8	4.8	15700.0	1

Top measurements by pChEMBL value

Target	Type	Rel.	Value	Units	pChEMBL	Assay	PubMed
G-protein coupled receptor 39	EC50	=	3.6	nM	8.44	Agonist activity at human GPR39 expressed in HEK293 cells by cAMP assay	25313322
Protein phosphatase 3 catalytic subunit alpha	IC50	=	1100.3	nM	5.96	DRUGMATRIX: Protein Serine/Threonine Phosphatase, PPP3CA (Calcineurin, PP2B) enz...	-
Carbonic anhydrase 2	IC50	=	1159.0	nM	5.94	DRUGMATRIX: Carbonic Anhydrase II enzyme inhibition (substrate: 4-Nitrophenyl ac...	-
Tyrosine-protein kinase Fyn	IC50	=	1877.9	nM	5.73	DRUGMATRIX: Protein Tyrosine Kinase, Fyn enzyme inhibition (substrate: Poly(Glu:...	-
Epidermal growth factor receptor	IC50	=	2188.4	nM	5.66	DRUGMATRIX: Protein Tyrosine Kinase, EGF Receptor enzyme inhibition (substrate: ...	-
Protein Gpr39	EC50	=	4038.0	nM	5.39	Agonist activity at rat GPR39 expressed in HEK293 cells by IP1 assay	25313322
Androgen receptor	Ki	=	4339.1	nM	5.36	DRUGMATRIX: Androgen (Testosterone) AR radioligand binding (ligand: [3H] Miboler...	-
Androgen receptor	IC50	=	6508.6	nM	5.19	DRUGMATRIX: Androgen (Testosterone) AR radioligand binding (ligand: [3H] Miboler...	-
Sodium-dependent noradrenaline transporter	Ki	=	6950.4	nM	5.16	DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-5...	-
Sodium-dependent noradrenaline transporter	IC50	=	7008.3	nM	5.15	DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-5...	-
Ubiquitin-conjugating enzyme E2 T	Kd	=	15700.0	nM	4.8	Binding affinity to N-terminally 6xHis-Smt3 tagged human Ube2T C86K/K91R/K95R mu...	28933844

PubMed	DOI	Target Context	# Activities
37466499	10.1021/acs.jmedchem.3c00368	Staphylococcus aureus	8
25313322	10.1021/ml500240d	G-protein coupled receptor 39	2
25313322	10.1021/ml500240d	Unchecked	2
25313322	10.1021/ml500240d	Protein Gpr39	1
25313322	10.1021/ml500240d	NON-PROTEIN TARGET	1
28933844	10.1021/acs.jmedchem.7b01071	Ubiquitin-conjugating enzyme E2 T	1
32619886	10.1016/j.ejmech.2020.112522	NCI-H3255	1
37466499	10.1021/acs.jmedchem.3c00368	Escherichia coli	1

Data from ChEMBL 36 via Core Engine