Assay Detail
Binding
CHEMBL1909123
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DRUGMATRIX: Carbonic Anhydrase II enzyme inhibition (substrate: 4-Nitrophenyl acetate (4-NPA))
1742
Total Activities
871
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Erythrocyte |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
DrugMatrix in vitro pharmacology data
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 871 | 5.94 | 7.07 |
| Ki | 871 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7002 | CIGLITAZONE | 2.0 | 2 | 7.07 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 2 | 7.00 |
| CHEMBL595 | PIOGLITAZONE | 4.0 | 2 | 6.94 |
| CHEMBL118 | CELECOXIB | 4.0 | 2 | 6.74 |
| CHEMBL1055 | CHLORTHALIDONE | 4.0 | 2 | 6.17 |
| CHEMBL408 | TROGLITAZONE | 4.0 | 2 | 6.01 |
| CHEMBL1200679 | ZINC CHLORIDE | 4.0 | 2 | 5.94 |
| CHEMBL121 | ROSIGLITAZONE | 4.0 | 2 | 5.39 |
| CHEMBL865 | VALDECOXIB | 4.0 | 2 | 5.34 |
| CHEMBL104 | CLOTRIMAZOLE | 4.0 | 2 | 4.52 |
| CHEMBL402794 | BIS(2-ETHYLHEXYL)PHTHALATE | — | 2 | 4.17 |
| CHEMBL1201346 | BALSALAZIDE | 4.0 | 2 | - |
| CHEMBL1598608 | AZASETRON | 2.0 | 2 | - |
| CHEMBL24 | ATENOLOL | 4.0 | 2 | - |
| CHEMBL108 | CARBAMAZEPINE | 4.0 | 2 | - |
| CHEMBL894 | BUPROPION | 4.0 | 2 | - |
| CHEMBL1077 | BROMFENAC | 4.0 | 2 | - |
| CHEMBL264374 | BEZAFIBRATE | 3.0 | 2 | - |
| CHEMBL415690 | BETADEX | 3.0 | 2 | - |
| CHEMBL277474 | ANTIPYRINE | 3.0 | 2 | - |
| CHEMBL44814 | CARBON TETRACHLORIDE | -1.0 | 2 | - |
| CHEMBL319244 | CAFFEIC ACID PHENETHYL ESTER | — | 2 | - |
| CHEMBL221753 | BENZETHONIUM CHLORIDE | 2.0 | 2 | - |
| CHEMBL701 | BACLOFEN | 4.0 | 2 | - |
| CHEMBL1095699 | AZASERINE | 2.0 | 2 | - |
| CHEMBL3084803 | ASTROMICIN | 2.0 | 2 | - |
| CHEMBL1200396 | BUPIVACAINE HYDROCHLORIDE | 4.0 | 2 | - |
| CHEMBL844 | BRIMONIDINE | 4.0 | 2 | - |
| CHEMBL1231530 | BETAMIPRON | 2.0 | 2 | - |
| CHEMBL12089 | BERBERINE CHLORIDE | 1.0 | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7002 | CIGLITAZONE | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL20 | ACETAZOLAMIDE | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL595 | PIOGLITAZONE | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL118 | CELECOXIB | IC50 | = | 181.0 | nM | 6.74 |
| CHEMBL1055 | CHLORTHALIDONE | IC50 | = | 677.0 | nM | 6.17 |
| CHEMBL408 | TROGLITAZONE | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL1200679 | ZINC CHLORIDE | IC50 | = | 1159.0 | nM | 5.94 |
| CHEMBL121 | ROSIGLITAZONE | IC50 | = | 4069.0 | nM | 5.39 |
| CHEMBL865 | VALDECOXIB | IC50 | = | 4574.0 | nM | 5.34 |
| CHEMBL104 | CLOTRIMAZOLE | IC50 | = | 30103.0 | nM | 4.52 |
| CHEMBL402794 | BIS(2-ETHYLHEXYL)PHTHALATE | IC50 | = | 66906.0 | nM | 4.17 |
| CHEMBL92401 | IPRONIAZID | IC50 | - | — | - | |
| CHEMBL91 | MICONAZOLE | IC50 | - | — | - | |
| CHEMBL92401 | IPRONIAZID | Ki | - | — | - | |
| CHEMBL1221512 | — | Ki | - | — | - | |
| CHEMBL19215 | METERGOLINE | Ki | - | — | - | |
| CHEMBL19215 | METERGOLINE | IC50 | - | — | - | |
| CHEMBL45 | MELATONIN | Ki | - | — | - | |
| CHEMBL45 | MELATONIN | IC50 | - | — | - | |
| CHEMBL1909068 | — | Ki | - | — | - | |
| CHEMBL1909068 | — | IC50 | - | — | - | |
| CHEMBL1237 | LISINOPRIL ANHYDROUS | Ki | - | — | - | |
| CHEMBL1237 | LISINOPRIL ANHYDROUS | IC50 | - | — | - | |
| CHEMBL1201193 | LEVOBUPIVACAINE | Ki | - | — | - | |
| CHEMBL1201193 | LEVOBUPIVACAINE | IC50 | - | — | - | |
| CHEMBL480 | LANSOPRAZOLE | Ki | - | — | - | |
| CHEMBL480 | LANSOPRAZOLE | IC50 | - | — | - | |
| CHEMBL878 | METOLAZONE | Ki | - | — | - | |
| CHEMBL878 | METOLAZONE | IC50 | - | — | - | |
| CHEMBL6437 | MIANSERIN | Ki | - | — | - | |
| CHEMBL1909067 | — | Ki | - | — | - | |
| CHEMBL503 | LOVASTATIN | Ki | - | — | - | |
| CHEMBL2106399 | KITASAMYCIN | Ki | - | — | - | |
| CHEMBL741 | LAMOTRIGINE | IC50 | - | — | - | |
| CHEMBL741 | LAMOTRIGINE | Ki | - | — | - | |
| CHEMBL1201237 | LEVOBUNOLOL | IC50 | - | — | - | |
| CHEMBL1201237 | LEVOBUNOLOL | Ki | - | — | - | |
| CHEMBL1909064 | LIPOPOLYSACCHARIDE E. COLI O55:B5 | IC50 | - | — | - | |
| CHEMBL1909064 | LIPOPOLYSACCHARIDE E. COLI O55:B5 | Ki | - | — | - | |
| CHEMBL1909067 | — | IC50 | - | — | - | |
| CHEMBL164290 | N-NITROSODIETHYLAMINE | Ki | - | — | - | |
| CHEMBL1201139 | MEGESTROL ACETATE | IC50 | - | — | - | |
| CHEMBL1201139 | MEGESTROL ACETATE | Ki | - | — | - | |
| CHEMBL1201151 | MESTRANOL | IC50 | - | — | - | |
| CHEMBL1201151 | MESTRANOL | Ki | - | — | - | |
| CHEMBL1354199 | METHSCOPOLAMINE BROMIDE | IC50 | - | — | - | |
| CHEMBL1354199 | METHSCOPOLAMINE BROMIDE | Ki | - | — | - | |
| CHEMBL86 | METOCLOPRAMIDE | IC50 | - | — | - | |
| CHEMBL86 | METOCLOPRAMIDE | Ki | - | — | - | |
| CHEMBL164290 | N-NITROSODIETHYLAMINE | IC50 | - | — | - |