Assay Detail
Binding
CHEMBL4020060
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to N-terminally 6xHis-Smt3 tagged human Ube2T C86K/K91R/K95R mutant expressed in Escherichia coli by ITC method
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Ubiquitin-conjugating enzyme E2 T (CHEMBL4105763) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Mind the Metal: A Fragment Library-Derived Zinc Impurity Binds the E2 Ubiquitin-Conjugating Enzyme Ube2T and Induces Structural Rearrangements.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 2 | 4.78 | 4.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1200679 | ZINC CHLORIDE | 4.0 | 1 | 4.80 |
| CHEMBL4077491 | — | — | 1 | 4.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1200679 | ZINC CHLORIDE | Kd | = | 15700.0 | nM | 4.80 |
| CHEMBL4077491 | — | Kd | = | 17700.0 | nM | 4.75 |