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Assay Detail

CHEMBL1909203

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
DRUGMATRIX: Protein Tyrosine Kinase, EGF Receptor enzyme inhibition (substrate: Poly(Glu:Tyr))
1742
Total Activities
871
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Cell Type Insect cells
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Epidermal growth factor receptor (CHEMBL203)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

DrugMatrix in vitro pharmacology data
Scott S. Auerbach, DrugMatrix¨ and ToxFX¨ Coordinator National Toxicology Program

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 871 5.47 6.73
Ki 871 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1909064 LIPOPOLYSACCHARIDE E. COLI O55:B5 2 6.73
CHEMBL1476898 CADMIUM ACETATE 2 6.61
CHEMBL64894 GENTIAN VIOLET 4.0 2 6.33
CHEMBL1458880 CADMIUM DICHLORIDE 2 6.31
CHEMBL305660 EBASTINE 4.0 2 6.25
CHEMBL12131 CLOSANTEL 2.0 2 6.25
CHEMBL290106 BITHIONOL 4.0 2 6.21
CHEMBL496 HEXACHLOROPHENE 4.0 2 6.13
CHEMBL404849 SULOCTIDIL 4.0 2 6.10
CHEMBL319244 CAFFEIC ACID PHENETHYL ESTER 2 6.00
CHEMBL954 ENCLOMIPHENE 3.0 2 5.98
CHEMBL1386 TRANSPLATIN 3.0 2 5.97
CHEMBL307145 PYROGALLOL -1.0 2 5.91
CHEMBL75880 PERHEXILINE 4.0 2 5.83
CHEMBL6067481 COLISTIN 4.0 2 5.82
CHEMBL86754 IODOQUINOL 2.0 2 5.72
CHEMBL1200679 ZINC CHLORIDE 4.0 2 5.66
CHEMBL306043 GOLD SODIUM THIOMALATE 2.0 2 5.62
CHEMBL11359 CISPLATIN 4.0 2 5.58
CHEMBL1009 LEVODOPA 4.0 2 5.54
CHEMBL1200528 CHROMIC CHLORIDE 4.0 2 5.53
CHEMBL24944 TRIBROMSALAN 4.0 2 5.53
CHEMBL479 THIORIDAZINE 4.0 2 5.53
CHEMBL787 MONTELUKAST 4.0 2 5.50
CHEMBL1016 CANDESARTAN 3.0 2 5.49
CHEMBL1221512 2 5.49
CHEMBL334255 CETYLPYRIDINIUM BROMIDE 2 5.46
CHEMBL83 TAMOXIFEN 4.0 2 5.45
CHEMBL17157 TERFENADINE 4.0 2 5.45
CHEMBL7002 CIGLITAZONE 2.0 2 5.33

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1909064 LIPOPOLYSACCHARIDE E. COLI O55:B5 IC50 = 188.0 nM 6.73
CHEMBL1476898 CADMIUM ACETATE IC50 = 244.0 nM 6.61
CHEMBL64894 GENTIAN VIOLET IC50 = 473.0 nM 6.33
CHEMBL1458880 CADMIUM DICHLORIDE IC50 = 486.0 nM 6.31
CHEMBL305660 EBASTINE IC50 = 559.1 nM 6.25
CHEMBL12131 CLOSANTEL IC50 = 564.0 nM 6.25
CHEMBL290106 BITHIONOL IC50 = 614.0 nM 6.21
CHEMBL496 HEXACHLOROPHENE IC50 = 748.6 nM 6.13
CHEMBL404849 SULOCTIDIL IC50 = 794.4 nM 6.10
CHEMBL319244 CAFFEIC ACID PHENETHYL ESTER IC50 = 1005.0 nM 6.00
CHEMBL954 ENCLOMIPHENE IC50 = 1050.0 nM 5.98
CHEMBL1386 TRANSPLATIN IC50 = 1063.3 nM 5.97
CHEMBL307145 PYROGALLOL IC50 = 1230.0 nM 5.91
CHEMBL75880 PERHEXILINE IC50 = 1485.2 nM 5.83
CHEMBL6067481 COLISTIN IC50 = 1500.0 nM 5.82
CHEMBL86754 IODOQUINOL IC50 = 1889.0 nM 5.72
CHEMBL1200679 ZINC CHLORIDE IC50 = 2188.4 nM 5.66
CHEMBL306043 GOLD SODIUM THIOMALATE IC50 = 2379.0 nM 5.62
CHEMBL11359 CISPLATIN IC50 = 2621.0 nM 5.58
CHEMBL1009 LEVODOPA IC50 = 2880.0 nM 5.54
CHEMBL1200528 CHROMIC CHLORIDE IC50 = 2955.0 nM 5.53
CHEMBL479 THIORIDAZINE IC50 = 2947.0 nM 5.53
CHEMBL24944 TRIBROMSALAN IC50 = 2987.0 nM 5.53
CHEMBL787 MONTELUKAST IC50 = 3197.0 nM 5.50
CHEMBL1016 CANDESARTAN IC50 = 3276.9 nM 5.49
CHEMBL1221512 IC50 = 3216.0 nM 5.49
CHEMBL334255 CETYLPYRIDINIUM BROMIDE IC50 = 3472.0 nM 5.46
CHEMBL17157 TERFENADINE IC50 = 3566.0 nM 5.45
CHEMBL83 TAMOXIFEN IC50 = 3553.0 nM 5.45
CHEMBL7002 CIGLITAZONE IC50 = 4655.0 nM 5.33
CHEMBL459 METHYLDOPA IC50 = 5228.0 nM 5.28
CHEMBL1200558 BACITRACIN IC50 = 5377.0 nM 5.27
CHEMBL58 MITOXANTRONE IC50 = 5385.9 nM 5.27
CHEMBL926 DOBUTAMINE IC50 = 5551.0 nM 5.26
CHEMBL603 ZAFIRLUKAST IC50 = 5751.0 nM 5.24
CHEMBL296419 ASTEMIZOLE IC50 = 6057.0 nM 5.22
CHEMBL434063 IC50 = 10896.0 nM 4.96
CHEMBL195437 4-OCTYLPHENOL IC50 = 16219.0 nM 4.79
CHEMBL1630578 TIRILAZAD IC50 = 20397.0 nM 4.69
CHEMBL18797 SULINDAC SULFIDE IC50 = 23981.0 nM 4.62
CHEMBL280998 CATECHOL IC50 = 26043.0 nM 4.58
CHEMBL71 CHLORPROMAZINE IC50 = 28868.0 nM 4.54
CHEMBL91 MICONAZOLE IC50 = 29256.0 nM 4.53
CHEMBL808 ECONAZOLE IC50 = 32404.0 nM 4.49
CHEMBL726 FLUPHENAZINE IC50 = 40107.0 nM 4.40
CHEMBL584 NELFINAVIR IC50 = 55629.0 nM 4.25
CHEMBL104 CLOTRIMAZOLE IC50 = 69421.0 nM 4.16
CHEMBL503 LOVASTATIN IC50 - -
CHEMBL741 LAMOTRIGINE IC50 - -
CHEMBL2106399 KITASAMYCIN Ki - -