Assay Detail
Binding
CHEMBL1909202
Review assay metadata, readout intent, target linkage, and publication context from the same page.
DRUGMATRIX: Protein Serine/Threonine Phosphatase, PPP3CA (Calcineurin, PP2B) enzyme inhibition (substrate: DiFMUP)
1742
Total Activities
871
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Protein phosphatase 3 catalytic subunit alpha (CHEMBL4445) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
DrugMatrix in vitro pharmacology data
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 871 | 5.24 | 5.96 |
| Ki | 871 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1200679 | ZINC CHLORIDE | 4.0 | 2 | 5.96 |
| CHEMBL83 | TAMOXIFEN | 4.0 | 2 | 4.51 |
| CHEMBL402794 | BIS(2-ETHYLHEXYL)PHTHALATE | — | 2 | - |
| CHEMBL135 | ESTRADIOL | 4.0 | 2 | - |
| CHEMBL113 | CAFFEINE | 4.0 | 2 | - |
| CHEMBL31184 | BENZO[DEF]CHRYSENE | 0.5 | 2 | - |
| CHEMBL1201346 | BALSALAZIDE | 4.0 | 2 | - |
| CHEMBL1598608 | AZASETRON | 2.0 | 2 | - |
| CHEMBL24 | ATENOLOL | 4.0 | 2 | - |
| CHEMBL277474 | ANTIPYRINE | 3.0 | 2 | - |
| CHEMBL108 | CARBAMAZEPINE | 4.0 | 2 | - |
| CHEMBL894 | BUPROPION | 4.0 | 2 | - |
| CHEMBL1077 | BROMFENAC | 4.0 | 2 | - |
| CHEMBL264374 | BEZAFIBRATE | 3.0 | 2 | - |
| CHEMBL415690 | BETADEX | 3.0 | 2 | - |
| CHEMBL319244 | CAFFEIC ACID PHENETHYL ESTER | — | 2 | - |
| CHEMBL221753 | BENZETHONIUM CHLORIDE | 2.0 | 2 | - |
| CHEMBL701 | BACLOFEN | 4.0 | 2 | - |
| CHEMBL1095699 | AZASERINE | 2.0 | 2 | - |
| CHEMBL3084803 | ASTROMICIN | 2.0 | 2 | - |
| CHEMBL211501 | ANTIMYCIN A | — | 2 | - |
| CHEMBL1458880 | CADMIUM DICHLORIDE | — | 2 | - |
| CHEMBL1200396 | BUPIVACAINE HYDROCHLORIDE | 4.0 | 2 | - |
| CHEMBL844 | BRIMONIDINE | 4.0 | 2 | - |
| CHEMBL1231530 | BETAMIPRON | 2.0 | 2 | - |
| CHEMBL12089 | BERBERINE CHLORIDE | 1.0 | 2 | - |
| CHEMBL14 | CARBACHOL | 4.0 | 2 | - |
| CHEMBL388590 | BENZBROMARONE | 4.0 | 2 | - |
| CHEMBL1200558 | BACITRACIN | 4.0 | 2 | - |
| CHEMBL515914 | AZARIBINE | 4.0 | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1200679 | ZINC CHLORIDE | IC50 | = | 1100.3 | nM | 5.96 |
| CHEMBL83 | TAMOXIFEN | IC50 | = | 30573.0 | nM | 4.51 |
| CHEMBL1201139 | MEGESTROL ACETATE | Ki | - | — | - | |
| CHEMBL1354199 | METHSCOPOLAMINE BROMIDE | Ki | - | — | - | |
| CHEMBL1201151 | MESTRANOL | IC50 | - | — | - | |
| CHEMBL1201151 | MESTRANOL | Ki | - | — | - | |
| CHEMBL2106399 | KITASAMYCIN | Ki | - | — | - | |
| CHEMBL480 | LANSOPRAZOLE | IC50 | - | — | - | |
| CHEMBL1221512 | — | Ki | - | — | - | |
| CHEMBL1221512 | — | IC50 | - | — | - | |
| CHEMBL164290 | N-NITROSODIETHYLAMINE | Ki | - | — | - | |
| CHEMBL164290 | N-NITROSODIETHYLAMINE | IC50 | - | — | - | |
| CHEMBL1373 | MODAFINIL | Ki | - | — | - | |
| CHEMBL1373 | MODAFINIL | IC50 | - | — | - | |
| CHEMBL91 | MICONAZOLE | Ki | - | — | - | |
| CHEMBL91 | MICONAZOLE | IC50 | - | — | - | |
| CHEMBL1909067 | — | Ki | - | — | - | |
| CHEMBL1909067 | — | IC50 | - | — | - | |
| CHEMBL503 | LOVASTATIN | Ki | - | — | - | |
| CHEMBL503 | LOVASTATIN | IC50 | - | — | - | |
| CHEMBL86 | METOCLOPRAMIDE | Ki | - | — | - | |
| CHEMBL1618305 | NALOXONAZINE | IC50 | - | — | - | |
| CHEMBL6437 | MIANSERIN | Ki | - | — | - | |
| CHEMBL6437 | MIANSERIN | IC50 | - | — | - | |
| CHEMBL1618305 | NALOXONAZINE | Ki | - | — | - | |
| CHEMBL86 | METOCLOPRAMIDE | IC50 | - | — | - | |
| CHEMBL21731 | MAPROTILINE | IC50 | - | — | - | |
| CHEMBL1354199 | METHSCOPOLAMINE BROMIDE | IC50 | - | — | - | |
| CHEMBL558 | MEXILETINE | IC50 | - | — | - | |
| CHEMBL558 | MEXILETINE | Ki | - | — | - | |
| CHEMBL165790 | IPRIFLAVONE | IC50 | - | — | - | |
| CHEMBL165790 | IPRIFLAVONE | Ki | - | — | - | |
| CHEMBL547 | ISOTRETINOIN | IC50 | - | — | - | |
| CHEMBL547 | ISOTRETINOIN | Ki | - | — | - | |
| CHEMBL534 | KETOTIFEN | IC50 | - | — | - | |
| CHEMBL534 | KETOTIFEN | Ki | - | — | - | |
| CHEMBL191 | LOSARTAN | IC50 | - | — | - | |
| CHEMBL191 | LOSARTAN | Ki | - | — | - | |
| CHEMBL1201139 | MEGESTROL ACETATE | IC50 | - | — | - | |
| CHEMBL21731 | MAPROTILINE | Ki | - | — | - | |
| CHEMBL86304 | MOCLOBEMIDE | IC50 | - | — | - | |
| CHEMBL86304 | MOCLOBEMIDE | Ki | - | — | - | |
| CHEMBL1630579 | MYRTECAINE | IC50 | - | — | - | |
| CHEMBL1630579 | MYRTECAINE | Ki | - | — | - | |
| CHEMBL741 | LAMOTRIGINE | IC50 | - | — | - | |
| CHEMBL741 | LAMOTRIGINE | Ki | - | — | - | |
| CHEMBL1201237 | LEVOBUNOLOL | IC50 | - | — | - | |
| CHEMBL1201237 | LEVOBUNOLOL | Ki | - | — | - | |
| CHEMBL1909064 | LIPOPOLYSACCHARIDE E. COLI O55:B5 | IC50 | - | — | - | |
| CHEMBL1909064 | LIPOPOLYSACCHARIDE E. COLI O55:B5 | Ki | - | — | - |