Assay Detail
Binding
CHEMBL3385545
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Inhibition of Mycobacterium tuberculosis ADK expressed in Escherichia coli BL21(DE3) cells using [3H]adenosine by liquid scintillation counting method
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium tuberculosis |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structural basis for inhibition of mycobacterial and human adenosine kinase by 7-substituted 7-(Het)aryl-7-deazaadenine ribonucleosides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 5.63 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3342670 | — | — | 1 | 6.52 |
| CHEMBL1814776 | — | — | 1 | 6.48 |
| CHEMBL3342669 | — | — | 1 | 6.22 |
| CHEMBL3342672 | — | — | 1 | 6.05 |
| CHEMBL1814771 | — | — | 1 | 5.75 |
| CHEMBL3342671 | — | — | 1 | 5.69 |
| CHEMBL1814767 | — | — | 1 | 5.68 |
| CHEMBL3342660 | — | — | 1 | 5.63 |
| CHEMBL1814772 | — | — | 1 | 5.36 |
| CHEMBL1814778 | — | — | 1 | 5.35 |
| CHEMBL3342659 | — | — | 1 | 5.31 |
| CHEMBL1814766 | — | — | 1 | 5.27 |
| CHEMBL1814770 | — | — | 1 | 5.18 |
| CHEMBL3342673 | — | — | 1 | 5.12 |
| CHEMBL3342664 | — | — | 1 | 4.88 |
| CHEMBL1814773 | — | — | 1 | - |
| CHEMBL1814775 | — | — | 1 | - |
| CHEMBL1814774 | — | — | 1 | - |
| CHEMBL1814779 | — | — | 1 | - |
| CHEMBL1814780 | — | — | 1 | - |
| CHEMBL1814777 | — | — | 1 | - |
| CHEMBL3342661 | — | — | 1 | - |
| CHEMBL3342662 | — | — | 1 | - |
| CHEMBL3342663 | — | — | 1 | - |
| CHEMBL3342674 | — | — | 1 | - |
| CHEMBL3342665 | — | — | 1 | - |
| CHEMBL3342666 | — | — | 1 | - |
| CHEMBL3342667 | — | — | 1 | - |
| CHEMBL3342668 | — | — | 1 | - |
| CHEMBL3342675 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3342670 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL1814776 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL3342669 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3342672 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL1814771 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL3342671 | — | IC50 | = | 2060.0 | nM | 5.69 |
| CHEMBL1814767 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL3342660 | — | IC50 | = | 2330.0 | nM | 5.63 |
| CHEMBL1814772 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL1814778 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL3342659 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL1814766 | — | IC50 | = | 5330.0 | nM | 5.27 |
| CHEMBL1814770 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL3342673 | — | IC50 | = | 7670.0 | nM | 5.12 |
| CHEMBL3342664 | — | IC50 | = | 13100.0 | nM | 4.88 |
| CHEMBL1814762 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1814763 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1814764 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1814765 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1814769 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1814768 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1814773 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1814775 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1814774 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL1814779 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1814780 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL1814777 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3342661 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3342662 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3342663 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3342674 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3342665 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3342666 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3342667 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3342668 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3342675 | — | IC50 | > | 10000.0 | nM | - |