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Compound Detail

CHEMBL1814765

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Nc1ncnc2c1c(-c1cccc3ccccc13)cn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O

Basic Information

ChEMBL ID CHEMBL1814765
Phase Preclinical
Structure Type MOL
InChI Key LQJPVHNGRTWBCV-QTQZEZTPSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
18
Publications
0
Known Names

Molecular Properties

392.4
MW (Da)
1.45
ALogP
8
HBA
4
HBD
126.7
PSA (Ų)
0.42
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C21H20N4O4
MW 392.42
Aromatic Rings 4
Heavy Atoms 29
NP-Likeness 0.62

Activity Summary

IC50 1 meas. best 5.73

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Mycobacterium tuberculosis
CHEMBL360
IC50 5.73 5.73 1870.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

Data from ChEMBL 36 via Core Engine