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Assay Detail

CHEMBL3385546

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Functional
Antimycobacterial activity against Mycobacterium bovis BCG assessed as microbial growth inhibition incubated for 21 days
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mycobacterium tuberculosis
Confidence 1 — Organism
Curated By Autocuration

Target

Mycobacterium tuberculosis (CHEMBL360)
Type ORGANISM
Organism Mycobacterium tuberculosis

Publication

Structural basis for inhibition of mycobacterial and human adenosine kinase by 7-substituted 7-(Het)aryl-7-deazaadenine ribonucleosides.
Snášel J, Nauš P, Dostál J, Hnízda A, Fanfrlík J, Brynda J, Bourderioux A, Dušek M, Dvořáková H, Stolaříková J, Zábranská H, Pohl R, Konečný P, Džubák P, Votruba I, Hajdúch M, Rezáčová P, Veverka V, Hocek M, Pichová I.
J Med Chem (2014) 57 : 8268 -8279
PubMed 25259627 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 36 5.50 6.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1814776 1 6.89
CHEMBL3342669 1 6.72
CHEMBL1814764 1 6.44
CHEMBL1814766 1 6.41
CHEMBL1814773 1 5.95
CHEMBL3342659 1 5.95
CHEMBL3342663 1 5.94
CHEMBL3342672 1 5.89
CHEMBL1814762 1 5.87
CHEMBL3342665 1 5.86
CHEMBL3342673 1 5.78
CHEMBL3342667 1 5.76
CHEMBL1814765 1 5.73
CHEMBL3342668 1 5.72
CHEMBL1814763 1 5.68
CHEMBL1814771 1 5.64
CHEMBL1814778 1 5.60
CHEMBL1814774 1 5.51
CHEMBL3342664 1 5.51
CHEMBL1814770 1 5.41
CHEMBL3342670 1 5.34
CHEMBL3342662 1 5.34
CHEMBL1814768 1 5.33
CHEMBL3342661 1 5.28
CHEMBL3342675 1 5.19
CHEMBL3342660 1 5.17
CHEMBL3342666 1 5.15
CHEMBL1814772 1 5.14
CHEMBL1814769 1 5.08
CHEMBL1814767 1 4.76

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1814776 IC50 = 130.0 nM 6.89
CHEMBL3342669 IC50 = 190.0 nM 6.72
CHEMBL1814764 IC50 = 360.0 nM 6.44
CHEMBL1814766 IC50 = 390.0 nM 6.41
CHEMBL1814773 IC50 = 1120.0 nM 5.95
CHEMBL3342659 IC50 = 1130.0 nM 5.95
CHEMBL3342663 IC50 = 1160.0 nM 5.94
CHEMBL3342672 IC50 = 1300.0 nM 5.89
CHEMBL1814762 IC50 = 1340.0 nM 5.87
CHEMBL3342665 IC50 = 1380.0 nM 5.86
CHEMBL3342673 IC50 = 1680.0 nM 5.78
CHEMBL3342667 IC50 = 1740.0 nM 5.76
CHEMBL1814765 IC50 = 1870.0 nM 5.73
CHEMBL3342668 IC50 = 1900.0 nM 5.72
CHEMBL1814763 IC50 = 2080.0 nM 5.68
CHEMBL1814771 IC50 = 2270.0 nM 5.64
CHEMBL1814778 IC50 = 2510.0 nM 5.60
CHEMBL3342664 IC50 = 3070.0 nM 5.51
CHEMBL1814774 IC50 = 3080.0 nM 5.51
CHEMBL1814770 IC50 = 3930.0 nM 5.41
CHEMBL3342670 IC50 = 4530.0 nM 5.34
CHEMBL3342662 IC50 = 4540.0 nM 5.34
CHEMBL1814768 IC50 = 4730.0 nM 5.33
CHEMBL3342661 IC50 = 5290.0 nM 5.28
CHEMBL3342675 IC50 = 6390.0 nM 5.19
CHEMBL3342660 IC50 = 6750.0 nM 5.17
CHEMBL3342666 IC50 = 7050.0 nM 5.15
CHEMBL1814772 IC50 = 7270.0 nM 5.14
CHEMBL1814769 IC50 = 8310.0 nM 5.08
CHEMBL1814767 IC50 = 17400.0 nM 4.76
CHEMBL3342671 IC50 = 44320.0 nM 4.35
CHEMBL1814775 IC50 = 48000.0 nM 4.32
CHEMBL1814777 IC50 = 69000.0 nM 4.16
CHEMBL3342674 IC50 = 74420.0 nM 4.13
CHEMBL1814780 IC50 > 100000.0 nM -
CHEMBL1814779 IC50 > 100000.0 nM -