Assay Detail
Binding
CHEMBL3385584
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of acetylcholinesterase (unknown origin) assessed as inhibition of acetylcholine hydrolysis after 30 mins by Ellmann's method
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Biotransformation of huperzine A by a fungal endophyte of Huperzia serrata furnished sesquiterpenoid-alkaloid hybrids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.67 | 9.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL395280 | HUPERZINE A | 2.0 | 1 | 9.27 |
| CHEMBL3338389 | — | — | 1 | 7.22 |
| CHEMBL3338388 | — | — | 1 | 6.96 |
| CHEMBL3338386 | — | — | 1 | 6.00 |
| CHEMBL3338387 | — | — | 1 | 5.66 |
| CHEMBL3355594 | — | — | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL395280 | HUPERZINE A | IC50 | = | 0.54 | nM | 9.27 |
| CHEMBL3338389 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3338388 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL3338386 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL3338387 | — | IC50 | = | 2170.0 | nM | 5.66 |
| CHEMBL3355594 | — | IC50 | = | 12110.0 | nM | 4.92 |