Assay Detail
Binding
CHEMBL3385908
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human factor10a assessed as reduction in hydrolysis of chromogenic substrate S-2765 by Cheng-Prusoff equation analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
How a β-D-glucoside side chain enhances binding affinity to thrombin of inhibitors bearing 2-chlorothiophene as P1 moiety: crystallography, fragment deconstruction study, and evaluation of antithrombotic properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.29 | 10.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3343301 | — | — | 1 | 10.05 |
| CHEMBL3343300 | — | — | 1 | 9.60 |
| CHEMBL3343299 | — | — | 1 | 9.22 |
| CHEMBL3343304 | — | — | 1 | 5.16 |
| CHEMBL3343302 | — | — | 1 | 4.94 |
| CHEMBL3343303 | — | — | 1 | 4.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3343301 | — | Ki | = | 0.09 | nM | 10.05 |
| CHEMBL3343300 | — | Ki | = | 0.25 | nM | 9.60 |
| CHEMBL3343299 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL3343304 | — | Ki | = | 6900.0 | nM | 5.16 |
| CHEMBL3343302 | — | Ki | = | 11600.0 | nM | 4.94 |
| CHEMBL3343303 | — | Ki | = | 18300.0 | nM | 4.74 |