Assay Detail
Binding
CHEMBL3385960
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of YAP/ GST-TEAD1 (unknown origin) interaction by surface plasmon resonance assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Transcriptional coactivator YAP1/Transcriptional enhancer factor TEF-1 (CHEMBL3430909) ↗| Type | PROTEIN-PROTEIN INTERACTION |
| Organism | Homo sapiens |
Publication
Structure-Based Design and Synthesis of Potent Cyclic Peptides Inhibiting the YAP-TEAD Protein-Protein Interaction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 5.98 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3335461 | — | — | 1 | 7.60 |
| CHEMBL3335458 | — | — | 1 | 7.39 |
| CHEMBL3335453 | — | — | 1 | 7.38 |
| CHEMBL3335463 | — | — | 1 | 7.12 |
| CHEMBL3335452 | — | — | 1 | 6.82 |
| CHEMBL3335456 | — | — | 1 | 6.51 |
| CHEMBL3335457 | — | — | 1 | 6.47 |
| CHEMBL3335459 | — | — | 1 | 6.46 |
| CHEMBL3335454 | — | — | 1 | 6.43 |
| CHEMBL3335460 | — | — | 1 | 6.42 |
| CHEMBL3335462 | — | — | 1 | 6.28 |
| CHEMBL3335455 | — | — | 1 | 6.21 |
| CHEMBL3335450 | — | — | 1 | 5.82 |
| CHEMBL3335451 | — | — | 1 | 5.77 |
| CHEMBL3335447 | — | — | 1 | 5.16 |
| CHEMBL3335437 | — | — | 1 | 4.60 |
| CHEMBL3335391 | — | — | 1 | 4.43 |
| CHEMBL3335444 | — | — | 1 | 4.37 |
| CHEMBL3335388 | — | — | 1 | 4.31 |
| CHEMBL3335446 | — | — | 1 | 4.07 |
| CHEMBL3335445 | — | — | 1 | - |
| CHEMBL3335448 | — | — | 1 | - |
| CHEMBL3335449 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3335461 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3335458 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL3335453 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL3335463 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL3335452 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3335456 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL3335457 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL3335459 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL3335454 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL3335460 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL3335462 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL3335455 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL3335450 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL3335451 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL3335447 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL3335437 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL3335391 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL3335444 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL3335388 | — | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL3335446 | — | IC50 | = | 85000.0 | nM | 4.07 |
| CHEMBL3335445 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3335448 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3335449 | — | IC50 | > | 100000.0 | nM | - |