Assay Detail
Binding
CHEMBL3385961
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of YAP/ GST-TEAD1 interaction in human Bel-7404 cells by GST pull-down assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Bel7404 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Transcriptional coactivator YAP1/Transcriptional enhancer factor TEF-1 (CHEMBL3430909) ↗| Type | PROTEIN-PROTEIN INTERACTION |
| Organism | Homo sapiens |
Publication
Structure-Based Design and Synthesis of Potent Cyclic Peptides Inhibiting the YAP-TEAD Protein-Protein Interaction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 7.42 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3335461 | — | — | 1 | 7.82 |
| CHEMBL3335453 | — | — | 1 | 7.75 |
| CHEMBL3335452 | — | — | 1 | 7.41 |
| CHEMBL3335451 | — | — | 1 | 6.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3335461 | — | Kd | = | 15.0 | nM | 7.82 |
| CHEMBL3335453 | — | Kd | = | 18.0 | nM | 7.75 |
| CHEMBL3335452 | — | Kd | = | 39.0 | nM | 7.41 |
| CHEMBL3335451 | — | Kd | = | 211.0 | nM | 6.68 |