Assay Detail
ADMET
CHEMBL3385975
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Inhibition of human recombinant CYP2C19 incubated for 5 mins by fluorescence assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Exploration of 3-Aminoazetidines as Triple Reuptake Inhibitors by Bioisosteric Modification of 3-α-Oxyazetidine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.72 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3331506 | — | — | 1 | 7.16 |
| CHEMBL3331469 | — | — | 1 | 6.57 |
| CHEMBL3331502 | — | — | 1 | 6.10 |
| CHEMBL3331503 | — | — | 1 | 5.99 |
| CHEMBL3331504 | — | — | 1 | 5.76 |
| CHEMBL1175 | DULOXETINE | 4.0 | 1 | 5.39 |
| CHEMBL3331508 | — | — | 1 | 5.27 |
| CHEMBL3331507 | — | — | 1 | 5.15 |
| CHEMBL3331484 | — | — | 1 | 5.09 |
| CHEMBL91 | MICONAZOLE | 4.0 | 1 | 4.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3331506 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL3331469 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL3331502 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL3331503 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL3331504 | — | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL1175 | DULOXETINE | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL3331508 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL3331507 | — | IC50 | = | 7060.0 | nM | 5.15 |
| CHEMBL3331484 | — | IC50 | = | 8080.0 | nM | 5.09 |
| CHEMBL91 | MICONAZOLE | IC50 | = | 17900.0 | nM | 4.75 |