Assay Detail
Binding
CHEMBL3386213
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Inhibition of GST-tagged rat CK1delta expressed in Escherichia coli using GST-p53 (1 to 64 residues) by SDS-PAGE based autoradiography
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Difluoro-dioxolo-benzoimidazol-benzamides as potent inhibitors of CK1δ and ε with nanomolar inhibitory activity on cancer cell proliferation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.74 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3337845 | — | — | 1 | 7.70 |
| CHEMBL3337854 | — | — | 1 | 7.40 |
| CHEMBL3337850 | — | — | 1 | 6.89 |
| CHEMBL3337846 | — | — | 1 | 6.85 |
| CHEMBL3337849 | — | — | 1 | 6.68 |
| CHEMBL3337851 | — | — | 1 | 6.58 |
| CHEMBL3337852 | — | — | 1 | 6.52 |
| CHEMBL3337853 | — | — | 1 | 6.26 |
| CHEMBL3337847 | — | — | 1 | 6.25 |
| CHEMBL3337848 | — | — | 1 | 6.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3337845 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3337854 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3337850 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3337846 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL3337849 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL3337851 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL3337852 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3337853 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL3337847 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL3337848 | — | IC50 | = | 570.0 | nM | 6.24 |