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Compound Detail

CHEMBL3337851

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O=C(Nc1nc2cc3c(cc2[nH]1)OC(F)(F)O3)c1cccc(OC(F)F)c1

Basic Information

ChEMBL ID CHEMBL3337851
Phase Preclinical
Structure Type MOL
InChI Key MESYSWLGSUWXIQ-UHFFFAOYSA-N
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

383.3
MW (Da)
3.74
ALogP
5
HBA
2
HBD
85.5
PSA (Ų)
0.67
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C16H9F4N3O4
MW 383.26
Aromatic Rings 3
Heavy Atoms 27
NP-Likeness -1.65

Activity Summary

IC50 3 meas. best 6.75

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Casein kinase I isoform delta
CHEMBL4484
IC50 6.75 6.665 180.0 2
Casein kinase I isoform epsilon
CHEMBL4937
IC50 6.5 6.5 320.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
25191940 10.1021/jm500600b Casein kinase I isoform delta 2
25191940 10.1021/jm500600b Casein kinase I isoform epsilon 1
25191940 10.1021/jm500600b Casein kinase I isoform gamma-3 1

Data from ChEMBL 36 via Core Engine