Assay Detail
Functional
CHEMBL3386513
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Antiviral activity against Hepatitis C virus genotype 1b in human HuH7 cells assessed as inhibition of viral replication after 72 hrs by luciferase reporter assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Derivatives of imidazotriazine and pyrrolotriazine C-nucleosides as potential new anti-HCV agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 6.30 | 8.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3337574 | — | — | 1 | 8.21 |
| CHEMBL3337575 | — | — | 1 | 6.77 |
| CHEMBL3337572 | — | — | 1 | 6.58 |
| CHEMBL3337577 | — | — | 1 | 6.16 |
| CHEMBL3337573 | — | — | 1 | 6.00 |
| CHEMBL2031677 | — | — | 1 | 5.89 |
| CHEMBL2031678 | — | — | 1 | 5.80 |
| CHEMBL3337576 | — | — | 1 | 5.75 |
| CHEMBL3337571 | — | — | 1 | 5.51 |
| CHEMBL3337578 | — | — | 1 | - |
| CHEMBL3337579 | — | — | 1 | - |
| CHEMBL3337580 | — | — | 1 | - |
| CHEMBL3337581 | — | — | 1 | - |
| CHEMBL3337582 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3337574 | — | EC50 | = | 6.2 | nM | 8.21 |
| CHEMBL3337575 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL3337572 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL3337577 | — | EC50 | = | 690.0 | nM | 6.16 |
| CHEMBL3337573 | — | EC50 | = | 990.0 | nM | 6.00 |
| CHEMBL2031677 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL2031678 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL3337576 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL3337571 | — | EC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL3337578 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL3337579 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL3337580 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL3337581 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL3337582 | — | EC50 | > | 50000.0 | nM | - |