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Compound Detail

CHEMBL3337576

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C[C@@]1(O)[C@H](O)[C@@H](CO)O[C@H]1c1cc(-c2ncco2)c2c(N)ncnn12

Basic Information

ChEMBL ID CHEMBL3337576
Phase Preclinical
Structure Type MOL
InChI Key VHEPEYVPDKHKNJ-ADGXKJENSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

347.3
MW (Da)
-0.49
ALogP
10
HBA
4
HBD
152.2
PSA (Ų)
0.49
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C15H17N5O5
MW 347.33
Aromatic Rings 3
Heavy Atoms 25
NP-Likeness 0.78

Activity Summary

EC50 1 meas. best 5.75

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Hepatitis C virus
CHEMBL379
EC50 5.75 5.75 1800.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Hepatitis C virus EC50 = 1800.0 nM 5.75 Antiviral activity against Hepatitis C virus genotype 1b in human HuH7 cells ass... 25288185

Literature References

PubMed DOI Target Context # Activities
25288185 10.1016/j.bmcl.2014.09.030 Hepatitis C virus 1
25288185 10.1016/j.bmcl.2014.09.030 ADMET 1

Data from ChEMBL 36 via Core Engine