Assay Detail
Binding
CHEMBL3386561
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Inhibition of Escherichia coli M15 recombinant IspC using 1-deoxy-D-xylulose 5-phosphate as substrate by photometric analysis
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
1-deoxy-D-xylulose 5-phosphate reductoisomerase (CHEMBL4091) ↗| Type | SINGLE PROTEIN |
| Organism | Escherichia coli K-12 |
Publication
Binding modes of reverse fosmidomycin analogs toward the antimalarial target IspC.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.10 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3341763 | — | — | 1 | 7.16 |
| CHEMBL3342259 | — | — | 1 | 6.85 |
| CHEMBL2164257 | FOSMIDOMYCIN SODIUM | — | 1 | 6.66 |
| CHEMBL2164256 | — | — | 1 | 6.54 |
| CHEMBL3342260 | — | — | 1 | 6.50 |
| CHEMBL3342262 | — | — | 1 | 6.35 |
| CHEMBL3342258 | — | — | 1 | 6.16 |
| CHEMBL3342261 | — | — | 1 | 5.82 |
| CHEMBL3342264 | — | — | 1 | 5.37 |
| CHEMBL3342265 | — | — | 1 | 4.96 |
| CHEMBL3342263 | — | — | 1 | 4.77 |
| CHEMBL3342266 | — | — | 1 | - |
| CHEMBL3342267 | — | — | 1 | - |
| CHEMBL3342268 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3341763 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL3342259 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL2164257 | FOSMIDOMYCIN SODIUM | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL2164256 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL3342260 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL3342262 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL3342258 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL3342261 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL3342264 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL3342265 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL3342263 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL3342266 | — | IC50 | = | 741000.0 | nM | - |
| CHEMBL3342267 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL3342268 | — | IC50 | > | 500000.0 | nM | - |