Assay Detail
Binding
CHEMBL3386589
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Inhibition of Mycobacterium tuberculosis DNA gyrase-mediated relaxed pBR322 DNA supercoiling by gel electrophoresis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium tuberculosis |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
DNA gyrase subunit A/DNA gyrase subunit B (CHEMBL3430898) ↗| Type | PROTEIN COMPLEX |
| Organism | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Publication
2-Phenylindole and Arylsulphonamide: Novel Scaffolds Bactericidal against Mycobacterium tuberculosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.41 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL36506 | NOVOBIOCIN | 4.0 | 1 | 7.82 |
| CHEMBL32 | MOXIFLOXACIN | 4.0 | 1 | 5.00 |
| CHEMBL3335464 | — | — | 1 | - |
| CHEMBL3335466 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL36506 | NOVOBIOCIN | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL32 | MOXIFLOXACIN | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3335464 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3335466 | — | IC50 | > | 100000.0 | nM | - |