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Assay Detail

CHEMBL3386600

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Functional
Agonist activity at human APJ receptor expressed in Chem-5 cells assessed as calcium mobilization by FLIPR assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type Chem-5
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Apelin receptor (CHEMBL1628481)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

The design and implementation of a generic lipopeptide scanning platform to enable the identification of 'locally acting' agonists for the apelin receptor.
McKeown SC, Zecri FJ, Fortier E, Taggart A, Sviridenko L, Adams CM, McAllister KH, Pin SS.
Bioorg Med Chem Lett (2014) 24 : 4871 -4875
PubMed 25241924 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 1 6.33 6.33

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3338677 1 6.33

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3338677 EC50 = 470.0 nM 6.33