Assay Detail
Binding
CHEMBL3386718
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of VHR (unknown origin) assessed as reduction in pNPP hydrolysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dual specificity protein phosphatase 3 (CHEMBL2635) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Fast identification of novel lymphoid tyrosine phosphatase inhibitors using target-ligand interaction-based virtual screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.57 | 5.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3360905 | — | — | 1 | 5.12 |
| CHEMBL3360906 | — | — | 1 | 4.30 |
| CHEMBL1774309 | — | — | 1 | 4.29 |
| CHEMBL3360908 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3360905 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL3360906 | — | IC50 | = | 50100.0 | nM | 4.30 |
| CHEMBL1774309 | — | IC50 | = | 50700.0 | nM | 4.29 |
| CHEMBL3360908 | — | IC50 | > | 100000.0 | nM | - |