Assay Detail
Functional
CHEMBL3386802
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Cytotoxicity against human AC1M88 cells after 48 hrs by MTT assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | AC1-M88 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Difluoro-dioxolo-benzoimidazol-benzamides as potent inhibitors of CK1δ and ε with nanomolar inhibitory activity on cancer cell proliferation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.33 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3337846 | — | — | 1 | 6.75 |
| CHEMBL3337852 | — | — | 1 | 6.40 |
| CHEMBL3337845 | — | — | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3337846 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL3337852 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL3337845 | — | EC50 | = | 1410.0 | nM | 5.85 |